Ghana international midfielder Kwadwo Asamoah (pictured) will need surgery after tearing cartilage and Rugani has a strained ligament.
The hardworking, energetic and tactically versatile player Asamoah and Juventus’ Italian defender Daniele Rugani were injured following the 1-0 win at Palermo in Serie A.
The Italian giants (Juventus) said on Sunday that both players are expected to return in 45 days.
Asamoah, 27, will also rule out for Ghana’s 2018 World Cup qualifier against Uganda on 7 October.
A double blow for the five-time Serie A champions with Medhi Benatia and Claudio Marchisio still out injured.
“Asamoah has suffered a rupture of the medial meniscus ligament in his right knee, while Rugani has a strained collateral lateral ligament in his right knee,” said the club statement.
Asamoah is expected to “undergo keyhole surgery”, while Rugani is set for more “moderate treatment”, added the statement.
Asamoah made his debut for the Ghana national team, Black Stars, in 2006, under French manager Claude Le Roy.